Anonymous
Mar 28
Describe JAK- STAT pathway?
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ChatGPT
Mar 28
The JAK-STAT pathway is a signaling pathway that plays a crucial role in the regulation of gene expression in response to various extracellular signals. It is named after two key components of the pathway: Janus kinase (JAK) and Signal Transducer and Activator of Transcription (STAT).
The pathway is initiated when a cytokine or growth factor binds to its corresponding receptor on the cell surface, leading to the activation of JAK proteins associated with the receptor. The activated JAK proteins then phosphorylate the receptor, creating docking sites for STAT proteins.
Once recruited to the receptor, STAT proteins are phosphorylated by JAK proteins, leading to their dimerization and translocation into the nucleus. In the nucleus, STAT dimers bind to specific DNA sequences, known as STAT response elements, and regulate the transcription of target genes.
The JAK-STAT pathway is involved in a wide range of cellular processes, including cell growth, differentiation, proliferation, and immune response. Dysregulation of this pathway has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions.
The pathway is initiated when a cytokine or growth factor binds to its corresponding receptor on the cell surface, leading to the activation of JAK proteins associated with the receptor. The activated JAK proteins then phosphorylate the receptor, creating docking sites for STAT proteins.
Once recruited to the receptor, STAT proteins are phosphorylated by JAK proteins, leading to their dimerization and translocation into the nucleus. In the nucleus, STAT dimers bind to specific DNA sequences, known as STAT response elements, and regulate the transcription of target genes.
The JAK-STAT pathway is involved in a wide range of cellular processes, including cell growth, differentiation, proliferation, and immune response. Dysregulation of this pathway has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions.
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Mar 28
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