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Jan 15

# meaning, causes mode of transmission major sign and symptoms treatment and prevention of giantism?

#Endocrine disorders?
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Jan 15
Giantism, also known as gigantism, is a rare condition characterized by excessive growth and height in individuals. It is usually caused by an overproduction of growth hormone (GH) during childhood and adolescence, due to a tumor in the pituitary gland called pituitary adenoma.

The mode of transmission of giantism is not genetic or contagious. It is typically caused by a non-inherited mutation in the genes responsible for regulating the production of growth hormone.

The major signs and symptoms of giantism include:

1. Excessive growth: Individuals with giantism experience rapid and continuous growth, resulting in significantly increased height compared to their peers.
2. Increased hand and foot size: The hands and feet may also grow larger than normal.
3. Facial changes: The facial features may become more pronounced, including a protruding jaw and enlarged nose.
4. Joint problems: The excessive growth can put strain on the joints, leading to joint pain and limited mobility.
5. Organ enlargement: Internal organs, such as the heart and lungs, may also enlarge, leading to potential complications.

Treatment for giantism primarily involves managing the overproduction of growth hormone. This may include:

1. Medications: Medications, such as somatostatin analogs or growth hormone receptor antagonists, can help regulate the production of growth hormone.
2. Surgery: Surgical removal of the pituitary tumor causing the excessive growth hormone production may be necessary in some cases.
3. Radiation therapy: In cases where surgery is not possible or unsuccessful, radiation therapy may be used to shrink the tumor and reduce growth hormone production.

Prevention of giantism is not possible as it is primarily caused by non-inherited genetic mutations. However, early detection and treatment of pituitary tumors can help prevent the progression of excessive growth and associated complications. Regular medical check-ups and monitoring of growth patterns in children can aid in early diagnosis.

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