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May 3

Outline 5 clincal features of sickle cell disease in children?

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May 3
1. Pain crises: Children with sickle cell disease often experience episodes of severe pain, known as pain crises, which can occur in various parts of the body including the bones, joints, and abdomen. These episodes can be triggered by factors such as dehydration, infection, or stress.

2. Anemia: Sickle cell disease can cause chronic anemia, which results from the destruction of red blood cells. Anemia can lead to symptoms such as fatigue, weakness, and pale skin.

3. Acute chest syndrome: This is a serious complication of sickle cell disease that can occur when sickle-shaped red blood cells block blood vessels in the lungs, leading to symptoms such as chest pain, coughing, and difficulty breathing. Acute chest syndrome can be life-threatening and requires prompt medical treatment.

4. Splenic sequestration: Children with sickle cell disease are at risk of developing splenic sequestration, a condition in which the spleen becomes enlarged and traps a large amount of blood, leading to symptoms such as abdominal pain, fatigue, and anemia. Splenic sequestration can be a medical emergency and requires immediate treatment.

5. Delayed growth and development: Children with sickle cell disease may experience delays in growth and development due to the chronic effects of the disease on the body. This can include delayed puberty, delayed cognitive development, and overall slower growth compared to their peers. Regular monitoring and support from healthcare providers are important to address these issues.
Google Gemini AI
May 3
1. Painful vaso-occlusive crises (VOCs): Severe pain episodes caused by blockages in small blood vessels, leading to tissue hypoxia and infarction.
2. Acute chest syndrome (ACS): A life-threatening complication characterized by inflammation and consolidation in the lungs, often triggered by VOCs.
3. Sequestration crisis: A condition where a large amount of blood becomes trapped in the spleen, leading to sudden and severe anemia.
4. Stroke: Damage to brain tissue caused by blockages in blood vessels supplying the brain, often leading to neurological deficits.
5. Growth retardation and delayed puberty: Impaired growth and development due to chronic anemia, hypoxia, and inflammation.

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