> #science , #health > Outline the main events of the post-eryrthrocytic phase of the plasmodium parasite in human?
Junisa Jusu (J. Grate)
more than 3 weeks ago

Outline the main events of the post-eryrthrocytic phase of the plasmodium parasite in human?

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more than 3 weeks ago
1. Invasion of hepatocytes: After being injected into the human host by an infected mosquito, the sporozoites of the Plasmodium parasite travel to the liver where they invade hepatocytes.

2. Development in hepatocytes: Inside the hepatocytes, the sporozoites undergo a series of transformations and develop into schizonts. These schizonts then undergo multiple rounds of asexual replication, resulting in the formation of thousands of merozoites.

3. Release of merozoites: Once mature, the schizonts rupture the hepatocytes, releasing the merozoites into the bloodstream.

4. Invasion of red blood cells: The released merozoites then invade red blood cells, where they continue their asexual replication cycle. Inside the red blood cells, the merozoites develop into trophozoites, which then mature into schizonts.

5. Rupture of red blood cells: Once mature, the schizonts rupture the red blood cells, releasing more merozoites into the bloodstream. This cycle of invasion, replication, and rupture of red blood cells leads to the characteristic symptoms of malaria, such as fever, chills, and anemia.

6. Differentiation into gametocytes: Some of the merozoites differentiate into male and female gametocytes, which can be taken up by a mosquito during a blood meal, completing the life cycle of the Plasmodium parasite.
Google Gemini AI
more than 3 weeks ago
Post-Erythrocytic Phase

1. Formation of Gametocytes:

- Within infected erythrocytes, some parasites differentiate into gametocytes:
- Male gametocytes (microgametocytes)
- Female gametocytes (macrogametocytes)

2. Gamete Exflagellation:

- Inside the mosquito midgut, microgametocytes release 4-8 motile gametes (microgametes).

3. Fertilization:

- A microgamete fertilizes a macrogamete, resulting in the formation of a zygote.

4. Oocyst Formation:

- The zygote develops into an ookinete, which penetrates the mosquito's midgut wall and forms an oocyst.

5. Sporozoite Formation:

- Inside the oocyst, the zygote undergoes multiple divisions, forming numerous sporozoites.

6. Sporozoite Release:

- When the oocyst matures, it ruptures, releasing sporozoites into the mosquito's hemocoel.

7. Transmission to Humans:

- During a blood meal by an infected mosquito, sporozoites are injected into human skin.
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