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Mar 14
There are several disorders related to dysfunction of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. Some of these disorders include:
1. GABA deficiency: This condition occurs when there is a lack of GABA production or release in the brain, leading to symptoms such as anxiety, insomnia, and seizures.
2. GABA receptor disorders: Mutations in the genes that code for GABA receptors can lead to abnormalities in GABA signaling, resulting in conditions such as epilepsy, autism, and mood disorders.
3. GABA transaminase deficiency: This rare genetic disorder impairs the breakdown of GABA in the brain, leading to an accumulation of the neurotransmitter and causing symptoms such as developmental delay and seizures.
4. GABAergic interneuron dysfunction: Dysfunction of GABA-producing interneurons in the brain can disrupt the balance of excitatory and inhibitory neurotransmission, contributing to conditions such as schizophrenia and epilepsy.
Treatment for GABA-related disorders may involve medications that enhance GABA signaling, such as benzodiazepines or anticonvulsants, as well as behavioral therapies and lifestyle modifications.
1. GABA deficiency: This condition occurs when there is a lack of GABA production or release in the brain, leading to symptoms such as anxiety, insomnia, and seizures.
2. GABA receptor disorders: Mutations in the genes that code for GABA receptors can lead to abnormalities in GABA signaling, resulting in conditions such as epilepsy, autism, and mood disorders.
3. GABA transaminase deficiency: This rare genetic disorder impairs the breakdown of GABA in the brain, leading to an accumulation of the neurotransmitter and causing symptoms such as developmental delay and seizures.
4. GABAergic interneuron dysfunction: Dysfunction of GABA-producing interneurons in the brain can disrupt the balance of excitatory and inhibitory neurotransmission, contributing to conditions such as schizophrenia and epilepsy.
Treatment for GABA-related disorders may involve medications that enhance GABA signaling, such as benzodiazepines or anticonvulsants, as well as behavioral therapies and lifestyle modifications.
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