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May 19

Give presentations of tertiary syphilis?

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May 19
Tertiary syphilis is the third and most severe stage of syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum. This stage typically occurs years after the initial infection if left untreated. Tertiary syphilis can affect various organs and systems in the body, leading to serious complications.

One presentation of tertiary syphilis is neurosyphilis, which occurs when the infection spreads to the central nervous system. This can result in symptoms such as headache, confusion, memory loss, and difficulty coordinating movements. In severe cases, neurosyphilis can cause paralysis, blindness, and even death.

Another presentation of tertiary syphilis is cardiovascular syphilis, which affects the heart and blood vessels. This can lead to symptoms such as chest pain, shortness of breath, and heart palpitations. Cardiovascular syphilis can cause serious complications such as aneurysms, heart failure, and damage to the heart valves.

Gummatous syphilis is another manifestation of tertiary syphilis, characterized by the formation of soft, tumor-like growths called gummas. These can develop in various tissues and organs, including the skin, bones, and liver. Gummatous syphilis can cause pain, swelling, and tissue damage, leading to disfigurement and functional impairment.

Overall, tertiary syphilis can have a profound impact on a person's health and quality of life if left untreated. It is important to seek prompt medical attention if you suspect you may have syphilis or if you have been diagnosed with the infection to prevent the progression to tertiary syphilis and its complications.
Google Gemini AI
May 19
Gummatous Syphilis (Stage 3 Syphilis)

Clinical Manifestations:

- Gummas: Raised, rubbery nodules that break down into ulcers
- Ulcers: Deep, painless, and have a punched-out appearance
- Nodules: Firm, painless, and may resemble acne or rosacea

- Aortic involvement: Dilatation and weakening of the aorta, leading to aneurysms
- Valvular heart disease: Damage to heart valves, causing regurgitation or stenosis

- Meningovascular syphilis: Inflammation of the meninges and blood vessels in the brain
- Tabes dorsalis: Progressive degeneration of the posterior columns of the spinal cord
- General paresis: Mental impairment characterized by dementia, psychosis, and seizures

- Iritis: Inflammation of the iris
- Optic atrophy: Damage to the optic nerve, leading to blindness

- Gummatous involvement of other organs, such as the liver, bones, and joints
- Cachexia: Severe weight loss and malnutrition


- Physical examination
- Serological tests (e.g., RPR, VDRL)
- Biopsy of gummas
- Cerebrospinal fluid analysis (for neurological involvement)


- Penicillin G for at least 3 weeks
- For allergic patients, alternative antibiotics such as erythromycin or tetracycline
- Asymptomatic or latent syphilis requires shorter treatment courses


- Cardiovascular disease: Aortic aneurysm, heart failure
- Neurological damage: Paralysis, impaired intellectual function
- Blindness
- Cachexia and death if untreated

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