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Jan 4

Mechanical and chemical digestion of carbohydrates, proteins and lipids, types of muscle:- ultrastructure, chemical composition, mechanism of contraction, mechanism of reflex actions?

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Jan 4
Mechanical and Chemical Digestion of Carbohydrates, Proteins, and Lipids:

Carbohydrates:
- Mechanical digestion of carbohydrates begins in the mouth, where the teeth break down food into smaller pieces.
- Chemical digestion of carbohydrates starts in the mouth as well, with the enzyme amylase breaking down complex carbohydrates into simpler sugars.
- In the small intestine, pancreatic amylase further breaks down carbohydrates into monosaccharides, such as glucose, fructose, and galactose, which can be absorbed into the bloodstream.

Proteins:
- Mechanical digestion of proteins starts in the mouth with chewing, but it is not significant.
- Chemical digestion of proteins begins in the stomach, where the enzyme pepsin breaks down proteins into smaller polypeptides.
- In the small intestine, pancreatic enzymes, such as trypsin and chymotrypsin, further break down polypeptides into smaller peptides and amino acids, which can be absorbed into the bloodstream.

Lipids:
- Mechanical digestion of lipids occurs in the mouth through chewing, but it is minimal.
- Chemical digestion of lipids begins in the small intestine, where bile salts emulsify large lipid droplets into smaller droplets, increasing the surface area for enzymes to act.
- Pancreatic lipase then breaks down triglycerides into fatty acids and monoglycerides, which can be absorbed into the bloodstream.

Types of Muscle - Ultrastructure, Chemical Composition, Mechanism of Contraction:

Skeletal Muscle:
- Ultrastructure: Skeletal muscle is composed of long, cylindrical cells called muscle fibers. These fibers contain multiple nuclei and are striated due to the arrangement of contractile proteins.
- Chemical Composition: Skeletal muscle is primarily composed of contractile proteins called actin and myosin, along with other proteins like troponin and tropomyosin.
- Mechanism of Contraction: Skeletal muscle contraction is initiated by the release of calcium ions, which bind to troponin, causing a conformational change. This change exposes the binding sites on actin, allowing myosin heads to attach and form cross-bridges. ATP hydrolysis provides energy for the myosin heads to pull the actin filaments, resulting in muscle contraction.

Cardiac Muscle:
- Ultrastructure: Cardiac muscle cells are branched and interconnected, forming a network. They contain a single nucleus and are also striated.
- Chemical Composition: Cardiac muscle has a similar chemical composition to skeletal muscle, with actin and myosin being the primary contractile proteins.
- Mechanism of Contraction: Cardiac muscle contraction is initiated by the generation of electrical impulses from specialized cells called pacemaker cells. These impulses spread through the cardiac muscle cells, leading to the release of calcium ions and subsequent muscle contraction.

Smooth Muscle:
- Ultrastructure: Smooth muscle cells are spindle-shaped and lack striations. They have a single nucleus and are not as organized as skeletal or cardiac muscle.
- Chemical Composition: Smooth muscle contains actin and myosin, similar to other muscle types, but the ratio of these proteins differs.
- Mechanism of Contraction: Smooth muscle contraction is regulated by calcium ions, which bind to calmodulin. This complex activates myosin light-chain kinase, leading to the phosphorylation of myosin. Phosphorylated myosin can then interact with actin, causing muscle contraction.

Mechanism of Reflex Actions:

Reflex actions are rapid, involuntary responses to stimuli that help protect the body or maintain homeostasis. The mechanism of reflex actions involves several steps:

1. Stimulus: A sensory receptor detects a stimulus, such as pain or pressure.
2. Sensory Neuron: The sensory receptor sends an electrical signal through a sensory neuron to the spinal cord or brain.
3. Integration: In the spinal cord or brain, the signal is processed and integrated with other information.
4. Motor Neuron: An electrical signal is sent through a motor neuron from the spinal cord or brain to the effector organ (muscle or gland).
5. Response: The effector organ carries out the appropriate response, such as muscle contraction or gland secretion, without conscious control.
6. Feedback: Sensory receptors may receive feedback from the response, which can modify or terminate the reflex action.

Overall, reflex actions allow the body to respond quickly to potentially harmful or beneficial stimuli, without the need for conscious thought or decision-making.
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