Modes of cell signaling ( juxtacrine)?

1. Direct cell-cell contact: In juxtacrine signaling, cells physically interact with each other through direct contact. This allows for the transmission of signals between neighboring cells.

2. Gap junctions: Gap junctions are specialized channels that allow for the direct exchange of ions and small molecules between adjacent cells. This type of communication is important for coordinating cellular activities and responses.

3. Cell adhesion molecules: Cell adhesion molecules are proteins that mediate cell-cell interactions by binding to receptors on neighboring cells. This interaction can trigger signaling pathways that regulate various cellular processes.

4. Notch signaling: Notch signaling is a juxtacrine signaling pathway that plays a critical role in cell fate determination and tissue development. Notch receptors on one cell interact with ligands on an adjacent cell, leading to the activation of downstream signaling cascades.

5. Eph-ephrin signaling: Eph-ephrin signaling is another juxtacrine signaling pathway that regulates cell adhesion, migration, and tissue patterning. Eph receptors on one cell interact with ephrin ligands on another cell, leading to bidirectional signaling between the two cells.